Week 2 NFL odds week 2 NFL betting lines NFL lines week 2
Game  Opening Spread Total points
Bengals@Browns  -6 Under/Over 44
Falcons@Cowboys -5 Under/Over 52
Bills@Dolphins +5.5 Under/Over 42
Panthers@Buccaneers -9 Under/Over 49
Broncos@Steelers -6.5 Under/Over 43
Lions@Packers -6 Under/Over 47.5
Jaguars@Titans -10.5 Under/Over 43
Rams@Eagles +1.5 Under/Over 46
Vikings@Colts -3 Under/Over 47.5
Giants@Bears -5.5 Under/Over 43
49ers@Jets +7 Under/Over 42.5
Washington@Cardinals -6.5 Under.Over 46
Ravens@Texans +6.5 Under/Over 52.5
Chiefs@Chargers +8.5 Under/Over 48.5
Patriots@Seahawks -4.5 Under/Over 45
Saints@Raiders +5.5 Under/Over 50.5

This week's NFL action takes us to gridiron central where the 49ers after last week loss at home to the Cardinals will face the Jets. But wait, there's plenty more where that came from!

Place your Bet here


The San Francisco 49ers take on the New York Jets on Sunday 20 September, at 1 PM EDT. Both teams come out of week one with losses, but it's the Jets who have the on-paper advantage over the 49ers following the 11 December 2016 win - 23:17. But that's old news for NFL betting fans! NFL betting week 2 will focus on giving the 49ers – Super Bowl runners-up – a huge advantage in this match. They are the clear favorites to win with money line NFL betting. Over their last 20 games, San Francisco's 15-5, while the Jets are 5-1 over the last 6 games at home. Plus, the 49ers average 20.0 PPG, while the Jets average 17.0 PPG.

Make your play with 49ers@Jets with NFL betting week 2.


The Buffalo Bills will be locking horns with the Miami Dolphins on Sunday 20 September, at 1 PM at Hard Rock Stadium, in Miami Gardens, FL. The Buffalo Bills are 1-0 up after NFL week 1. The Buffalo Bills are heavy favs to run away with this match. As it stands the Bills are 4-2 ATS in their last 6 vs the Dolphins. The Bills are averaging 27.0 PPG while the Dolphins are averaging just 11.0 PPG. Can the Bills win the AFC East for the first time in a quarter century? Pundits seem to think so. When the Bills played the Jets, they won 27-17. They can do it again!

Make your play with Bills@Dolphins with NFL lines week 2.

For more NFL week 2 bettings previews click here: NFL lines week 2 and NFL odds week 2


The Minnesota Vikings travel to Lucas Oil Stadium to take on the Indianapolis Colts. Coming out of week 1, the Vikings lost to the Packers, while the Colts are also 0-1 down. This gridiron match kicks off on Sunday 20 September, at 1 PM EDT. The last time these two teams played was 18 December 2016 when the Colts beat the Vikings 34:6. As a sports bettor, you may wish to focus on defensive end Yannick Ngakoue again, despite his dismal showing against Rogers and the Packers in week 1. The Colts have concerns over Marlon Mack, but Hines and Taylor are still there. As a football fan, you’re probably going to want to go with the Vikings on this one, but it’s going to be a close call.

Make your play with Vikings@Colts with NFL odds week 2.


The Detroit Lions (23-27 to Chicago Bears) come up against a formidable team in the Green Bay Packers on Sunday 20 September, at 1 PM EDT. The Packers won their last game in week one (43-34 against the Vikings), and they also have the advantage over the Lions from the last meeting on December 29, 2019, when they won 23:20. This match takes place at Lambeau Field, in Green Bay. Oddsmakers have the Lions as the underdogs and the Packers as the favorites. Consider this stat when you place your bets on this match: Detroit averaged 23.0 PPG, while Green Bay averaged 43.0 PPG.

Make your play with Lions@Packers with NFL lines week 2.


The Atlanta Falcons lost their opening match 25-38 to the Seattle Seahawks. They are up against the Dallas Cowboys – who tussled with the Los Angeles Rams, narrowly losing 17-20. As far as team morale goes, the Cowboys will be hungry for victory when they lock horns with the Falcons on Sunday at 1 PM EDT at AT&T Stadium, in Arlington Texas. When these two teams previously met, on 18 November 2018, the Cowboys narrowly edged the Falcons 22-19. As a sports bettor, you have to go with the Cowboys on this one. They are eager to hit the ground running with a big win, and the odds show them as favs. Watch Dak Prescott, Cooper, Elliott, and Lamb against the Falcons.

Make your play with Falcons@Cowboys with NFL odds week 2.


The New York Giants and the Chicago Bears will square off on Sunday, 20 September at 1 PM EDT at Soldier Field, in Chicago. The Bears had a great end to week one, as they narrowly defeated the Detroit Lions 27-23. In the last head-to-head, the Bears beat the Giants 19-14 (24 November 2019), so they are definitely in the ascendancy. In the NFC East/NFC North tussle, the Bears have an additional day of rest, since the Giants played on Monday 14 September (Giants and Steelers). Straight up – the Bears are odds-on favorites for the win. While Mitch Tribusky disappointed somewhat against the Lions in the first half, he will be determined to QB like a boss for his team this time round!

Make your play with Giants@Bears with NFL lines week 2.

*Photo courtesy of Phelan M. Ebenhack and AP

About the Author
Brett Chatz

Brett is an internationally published sports journalist, political analyst, and medical fiction author. His commentary is seen in The Star, The Citizen, Tampa Bay Times, The Street, The Sowetan, The Sunday Times, The Sunday Independent, and across hundreds of online and print media platforms. He is the author of ‘Cricket Chatz’ and the highly-acclaimed, ‘Serum’. 

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